SEQ ID NO 45
  LENGTH: 4659
  TYPE: DNA
  ORGANISM: Homo sapiens
  FEATURE: 
  NAME/KEY: CDS
  LOCATION: (1)..(4659)
  SEQUENCE: 45
        atg ggg agc ttg cag caa gcc ctt gtg tgc ttt gaa aag agg ctc gtg      48
        Met Gly Ser Leu Gln Gln Ala Leu Val Cys Phe Glu Lys Arg Leu Val
          1               5                  10                  15
       gtt gct cat gaa ctt gga gag gcc ttc aat aaa gcc cag gcc tat gga       96
       Val Ala His Glu Leu Gly Glu Ala Phe Asn Lys Ala Gln Ala Tyr Gly
                    20                  25                  30
       gag ctg gga agt ctg cac agc caa tta ggg aat tac gaa caa gcc att      144
       Glu Leu Gly Ser Leu His Ser Gln Leu Gly Asn Tyr Glu Gln Ala Ile
                35                  40                  45
       tcc tgc ctt gaa cgc cag ctg aac att gct aga gat atg aaa gac cga      192
       Ser Cys Leu Glu Arg Gln Leu Asn Ile Ala Arg Asp Met Lys Asp Arg
            50                  55                  60
       gcc ctg gag agt gac gca gcc tgt ggc ctg ggg ggc gtt tac cag cag      240
       Ala Leu Glu Ser Asp Ala Ala Cys Gly Leu Gly Gly Val Tyr Gln Gln
        65                  70                  75                  80
       atg ggg gag tat gac aca gcc ctg cag tac cac cag ctt gat cta cag      288
       Met Gly Glu Tyr Asp Thr Ala Leu Gln Tyr His Gln Leu Asp Leu Gln
                        85                  90                  95
       ata gca gag gaa acc aac aac ccc acg tgc cag ggc cga gcc tat ggg      336
       Ile Ala Glu Glu Thr Asn Asn Pro Thr Cys Gln Gly Arg Ala Tyr Gly
                   100                 105                 110
       aac ctg ggc ctg act tat gaa tcc ctg ggc acc ttc gag agg gct gtg      384
       Asn Leu Gly Leu Thr Tyr Glu Ser Leu Gly Thr Phe Glu Arg Ala Val
               115                 120                 125
       gtc tat caa gaa cag cac ttg agc att gct gca cag atg aat gac ttg      432
       Val Tyr Gln Glu Gln His Leu Ser Ile Ala Ala Gln Met Asn Asp Leu
           130                 135                 140
       gcg gcc aag acg gtg tca tat agt agc ctt gga agg acc cat cat gcc      480
       Ala Ala Lys Thr Val Ser Tyr Ser Ser Leu Gly Arg Thr His His Ala
       145                 150                 155                 160
       ttg cag aac tat tcc caa gca gtc atg tac tta cag gaa ggt tta agg      528
       Leu Gln Asn Tyr Ser Gln Ala Val Met Tyr Leu Gln Glu Gly Leu Arg
                       165                 170                 175
       tta gct gag caa ctg ggc cga aga gaa gat gag gca aaa att cgc cat      576
       Leu Ala Glu Gln Leu Gly Arg Arg Glu Asp Glu Ala Lys Ile Arg His
                   180                 185                 190
       ggc ctt ggc ctc tcc ctt tgg gct agt gga aac ttg gag gag gcc caa      624
       Gly Leu Gly Leu Ser Leu Trp Ala Ser Gly Asn Leu Glu Glu Ala Gln
               195                 200                 205
       cac cag ctt tat agg gca tca gcc ttg ttt gaa aca atc cga cat gag      672
       His Gln Leu Tyr Arg Ala Ser Ala Leu Phe Glu Thr Ile Arg His Glu
           210                 215                 220
       gca cag ctg agc acg gac tac aaa ctc tcc ctc ttt gac ctg cag aca      720
       Ala Gln Leu Ser Thr Asp Tyr Lys Leu Ser Leu Phe Asp Leu Gln Thr
       225                 230                 235                 240
       tca tcc tac cag gcc ttg cag cgg gtg ctc gtc agc cta ggc cat cat      768
       Ser Ser Tyr Gln Ala Leu Gln Arg Val Leu Val Ser Leu Gly His His
                       245                 250                 255
       gat gaa gcc ctg gct gtg gca gaa agg gga cgg aca agg gca ttt gct      816
       Asp Glu Ala Leu Ala Val Ala Glu Arg Gly Arg Thr Arg Ala Phe Ala
                   260                 265                 270
       gat ctt ctg gtg gaa cga caa aca gga caa caa gac tcc gac ccc tac      864
       Asp Leu Leu Val Glu Arg Gln Thr Gly Gln Gln Asp Ser Asp Pro Tyr
               275                 280                 285
       tcc cca gtc act att gat cag atc tta gag atg gta aat ggc cag agg      912
       Ser Pro Val Thr Ile Asp Gln Ile Leu Glu Met Val Asn Gly Gln Arg
           290                 295                 300
       gga cta gtg ctt tac tat tcc ctg gct gca ggc tat ctg tat agc tgg      960
       Gly Leu Val Leu Tyr Tyr Ser Leu Ala Ala Gly Tyr Leu Tyr Ser Trp
       305                 310                 315                 320
       ctg ctg gct cct ggg gca gga att gtg aag ttt cat gaa cac tac ctg     1008
       Leu Leu Ala Pro Gly Ala Gly Ile Val Lys Phe His Glu His Tyr Leu
                       325                 330                 335
       ggt gag aac aca gtg gaa aac tca agt gac ttc cag gcc agc agc agt     1056
       Gly Glu Asn Thr Val Glu Asn Ser Ser Asp Phe Gln Ala Ser Ser Ser
                   340                 345                 350
       gta acc ctt cca aca gca acc ggc tca gcc ctg gag cag cac att gcc     1104
       Val Thr Leu Pro Thr Ala Thr Gly Ser Ala Leu Glu Gln His Ile Ala
               355                 360                 365
       agt gtc cgg gag gcc ctg ggg gtg gag tct cac tac tca agg gcc tgt     1152
       Ser Val Arg Glu Ala Leu Gly Val Glu Ser His Tyr Ser Arg Ala Cys
           370                 375                 380
       gcc agc agt gag aca gag agt gaa gcg gga gac atc atg gac cag caa     1200
       Ala Ser Ser Glu Thr Glu Ser Glu Ala Gly Asp Ile Met Asp Gln Gln
       385                 390                 395                 400
       ttt gaa gag atg aac aac aaa ctc aac tcg gtc act gac ccc act ggc     1248
       Phe Glu Glu Met Asn Asn Lys Leu Asn Ser Val Thr Asp Pro Thr Gly
                       405                 410                 415
       ttt ctg cgg atg gtt cgc cgc aat aac ctg ttt aac agg agc tgc cag     1296
       Phe Leu Arg Met Val Arg Arg Asn Asn Leu Phe Asn Arg Ser Cys Gln
                   420                 425                 430
       agc atg acg agc ctg ttc agt aac act gtg tca ccg acc cag gac ggg     1344
       Ser Met Thr Ser Leu Phe Ser Asn Thr Val Ser Pro Thr Gln Asp Gly
               435                 440                 445
       acc tcc tct ctt ccc agg agg cag agc tcg ttt gcc aag ccc ccg ctc     1392
       Thr Ser Ser Leu Pro Arg Arg Gln Ser Ser Phe Ala Lys Pro Pro Leu
           450                 455                 460
       cgt gcc ctg tat gac ctg ctc atc gcg ccc atg gaa ggg ggc ctg atg     1440
       Arg Ala Leu Tyr Asp Leu Leu Ile Ala Pro Met Glu Gly Gly Leu Met
       465                 470                 475                 480
       cac tcc agc ggc ccc gtg ggc cgg cac cgg cag ctc atc ctg gtt ctg     1488
       His Ser Ser Gly Pro Val Gly Arg His Arg Gln Leu Ile Leu Val Leu
                       485                 490                 495
       gag ggg gag ctc tac ctc att cct ttc gcc ctc ctg aag gga agc tcc     1536
       Glu Gly Glu Leu Tyr Leu Ile Pro Phe Ala Leu Leu Lys Gly Ser Ser
                   500                 505                 510
       tcc aat gag tac ctc tac gag cgc ttc ggc ctc ctt gct gtc cct tcc     1584
       Ser Asn Glu Tyr Leu Tyr Glu Arg Phe Gly Leu Leu Ala Val Pro Ser
               515                 520                 525
       atc cgc tcc ctc agc gtg cag tcc aag tct cac tta cgg aag aac ccg     1632
       Ile Arg Ser Leu Ser Val Gln Ser Lys Ser His Leu Arg Lys Asn Pro
           530                 535                 540
       ccc aca tac tcc agc tcc aca tcc atg gcg gct gtc atc ggc aac ccc     1680
       Pro Thr Tyr Ser Ser Ser Thr Ser Met Ala Ala Val Ile Gly Asn Pro
       545                 550                 555                 560
       aag cta cca tcg gcc gtg atg gac agg tgg ctg tgg ggg ccc atg cca     1728
       Lys Leu Pro Ser Ala Val Met Asp Arg Trp Leu Trp Gly Pro Met Pro
                       565                 570                 575
       tcg gcc gag gaa gag gcc tac atg gtg tcc gag ctg ctg ggc tgc cag     1776
       Ser Ala Glu Glu Glu Ala Tyr Met Val Ser Glu Leu Leu Gly Cys Gln
                   580                 585                 590
       ccc cta gtg ggc agt gtg gcc acc aag gag agg gtc atg agt gcc ctg     1824
       Pro Leu Val Gly Ser Val Ala Thr Lys Glu Arg Val Met Ser Ala Leu
               595                 600                 605
       acc cag gct gaa tgc gtc cac ttt gcc acc cac atc tcc tgg aag ctg     1872
       Thr Gln Ala Glu Cys Val His Phe Ala Thr His Ile Ser Trp Lys Leu
           610                 615                 620
       tcg gcc ttg gtc ctc acg ccc agc atg gac ggc aac cct gcc agc agc     1920
       Ser Ala Leu Val Leu Thr Pro Ser Met Asp Gly Asn Pro Ala Ser Ser
       625                 630                 635                 640
       aag agc tcc ttc ggc cac ccc tac acg atc cct gag tcc ttg cgg gtg     1968
       Lys Ser Ser Phe Gly His Pro Tyr Thr Ile Pro Glu Ser Leu Arg Val
                       645                 650                 655
       cag gac gat gcc agt gat ggg gag agc atc tcg gac tgc ccg ccc ctg     2016
       Gln Asp Asp Ala Ser Asp Gly Glu Ser Ile Ser Asp Cys Pro Pro Leu
                   660                 665                 670
       cag gag ctg ctg ctt act gcc gcc gac gtc ctg gac ctg cag ctg cct     2064
       Gln Glu Leu Leu Leu Thr Ala Ala Asp Val Leu Asp Leu Gln Leu Pro
               675                 680                 685
       gtg aag ctg gtg gtg ctt ggc tcc tcc cag gag tcc aac agc aaa gtc     2112
       Val Lys Leu Val Val Leu Gly Ser Ser Gln Glu Ser Asn Ser Lys Val
           690                 695                 700
       gca gcc gac ggg gtc atc gcg ctg aca agg gcc ttc ctg gct gcc ggc     2160
       Ala Ala Asp Gly Val Ile Ala Leu Thr Arg Ala Phe Leu Ala Ala Gly
       705                 710                 715                 720
       gct cag tgt gtc ctc gtg tct ctg tgg cct gtg cca gtg gct gct ttt     2208
       Ala Gln Cys Val Leu Val Ser Leu Trp Pro Val Pro Val Ala Ala Phe
                       725                 730                 735
       aag atg ttc atc cat gcc ttc tac tca tcc ctg ctg aac ggc ctg aaa     2256
       Lys Met Phe Ile His Ala Phe Tyr Ser Ser Leu Leu Asn Gly Leu Lys
                   740                 745                 750
       gcc agc gcc gcc ctg ggg gag gcc atg aag gtg gtg cag agc agc aag     2304
       Ala Ser Ala Ala Leu Gly Glu Ala Met Lys Val Val Gln Ser Ser Lys
               755                 760                 765
       gcc ttc tcg cac ccc tcc aac tgg gca ggg ttc atg ctc atc ggg agt     2352
       Ala Phe Ser His Pro Ser Asn Trp Ala Gly Phe Met Leu Ile Gly Ser
           770                 775                 780
       gac gtt aag ctg aac agc ccc tca tca ctc atc ggc cag gcc ctc aca     2400
       Asp Val Lys Leu Asn Ser Pro Ser Ser Leu Ile Gly Gln Ala Leu Thr
       785                 790                 795                 800
       gag atc ctg cag cac ccg gag cgt gcg cgg gac gcc ctg cga gtg ctg     2448
       Glu Ile Leu Gln His Pro Glu Arg Ala Arg Asp Ala Leu Arg Val Leu
                       805                 810                 815
       ctg cac ctg gtg gag aaa tcc ctg cag cgc atc cag aat ggg cag cgc     2496
       Leu His Leu Val Glu Lys Ser Leu Gln Arg Ile Gln Asn Gly Gln Arg
                   820                 825                 830
       aat gcc atg tac aca tcc cag cag agt gtg gag aac aaa gtg ggc ggc     2544
       Asn Ala Met Tyr Thr Ser Gln Gln Ser Val Glu Asn Lys Val Gly Gly
               835                 840                 845
       atc cct ggc tgg cag gcc ctc ctc acc gct gtg ggc ttc cgg ctg gac     2592
       Ile Pro Gly Trp Gln Ala Leu Leu Thr Ala Val Gly Phe Arg Leu Asp
           850                 855                 860
       ccc cca acc agt ggc ctg cca gcg gct gtc ttc ttc cca acc tcc gac     2640
       Pro Pro Thr Ser Gly Leu Pro Ala Ala Val Phe Phe Pro Thr Ser Asp
       865                 870                 875                 880
       ccg ggc gac cgg ctc cag cag tgc agc agc aca ctc cag tcc ctg ctg     2688
       Pro Gly Asp Arg Leu Gln Gln Cys Ser Ser Thr Leu Gln Ser Leu Leu
                       885                 890                 895
       ggt ctg ccc aat cct gcc ctc caa gcc ctt tgc aaa ctc atc act gcc     2736
       Gly Leu Pro Asn Pro Ala Leu Gln Ala Leu Cys Lys Leu Ile Thr Ala
                   900                 905                 910
       tcc gag acg ggc gag cag ctc atc agc cgg gct gtt aaa aat atg gtt     2784
       Ser Glu Thr Gly Glu Gln Leu Ile Ser Arg Ala Val Lys Asn Met Val
               915                 920                 925
       gga atg ctc cac cag gtg ctg gtt cag ctc cag gct ggc gag aag gag     2832
       Gly Met Leu His Gln Val Leu Val Gln Leu Gln Ala Gly Glu Lys Glu
           930                 935                 940
       cag gac ttg gca tca gct ccc att cag gtc tcc atc agc gtc cag ctg     2880
       Gln Asp Leu Ala Ser Ala Pro Ile Gln Val Ser Ile Ser Val Gln Leu
       945                 950                 955                 960
       tgg cgg ctc ccg gga tgc cac gag ttc ctg gca gct cta ggt ttt gat     2928
       Trp Arg Leu Pro Gly Cys His Glu Phe Leu Ala Ala Leu Gly Phe Asp
                       965                 970                 975
       ctc tgt gaa gtt ggt cag gag gaa gta atc ctg aaa acc ggg aag caa     2976
       Leu Cys Glu Val Gly Gln Glu Glu Val Ile Leu Lys Thr Gly Lys Gln
                   980                 985                 990
       gct aat cga cgg act gtg cac ttc gcg ctc cag tcc ctg ctg tct ctg     3024
       Ala Asn Arg Arg Thr Val His Phe Ala Leu Gln Ser Leu Leu Ser Leu
               995                1000                1005
       ttt gat tct act gag cta ccc aag cgc ctc agc ctt gac agc tcc tcc     3072
       Phe Asp Ser Thr Glu Leu Pro Lys Arg Leu Ser Leu Asp Ser Ser Ser
          1010                1015                1020
       tcc ctc gag tct ctt gct tct gct cag tct gtt tcc aac gcc ctg ccc     3120
       Ser Leu Glu Ser Leu Ala Ser Ala Gln Ser Val Ser Asn Ala Leu Pro
      1025                1030                1035                1040
       ttg ggt tac cag caa ccc ccc ttc tct ccc acc ggt gcg gac agc atc     3168
       Leu Gly Tyr Gln Gln Pro Pro Phe Ser Pro Thr Gly Ala Asp Ser Ile
                      1045                1050                1055
       gcc tca gat gcc atc tct gtg tac agt ctg agc tcc att gcc tcc tca     3216
       Ala Ser Asp Ala Ile Ser Val Tyr Ser Leu Ser Ser Ile Ala Ser Ser
                  1060                1065                1070
       atg agc ttt gtc tcc aaa ccc gag ggt gga tca gag ggt gga ggc ccc     3264
       Met Ser Phe Val Ser Lys Pro Glu Gly Gly Ser Glu Gly Gly Gly Pro
              1075                1080                1085
       gga gga cgg cag gac cat gac cgg tcc aag aac gct tac ctg cag aga     3312
       Gly Gly Arg Gln Asp His Asp Arg Ser Lys Asn Ala Tyr Leu Gln Arg
          1090                1095                1100
       tcc acc ctg cct agg agc cag ctg cct ccc cag acc cgc cct gca ggc     3360
       Ser Thr Leu Pro Arg Ser Gln Leu Pro Pro Gln Thr Arg Pro Ala Gly
      1105                1110                1115                1120
       aac aaa gat gaa gaa gaa tat gaa ggg ttt tct atc atc agt aac gag     3408
       Asn Lys Asp Glu Glu Glu Tyr Glu Gly Phe Ser Ile Ile Ser Asn Glu
                      1125                1130                1135
       ccc ttg gcg acc tac caa gaa aac cga aac aca tgc ttc tca cca gac     3456
       Pro Leu Ala Thr Tyr Gln Glu Asn Arg Asn Thr Cys Phe Ser Pro Asp
                  1140                1145                1150
       cac aaa caa ccc caa cct ggg aca gcc gga ggc atg aga gtc tcg gtg     3504
       His Lys Gln Pro Gln Pro Gly Thr Ala Gly Gly Met Arg Val Ser Val
              1155                1160                1165
       agc tcc aaa ggg agc atc agc act cca aat tct cca gtg aaa atg act     3552
       Ser Ser Lys Gly Ser Ile Ser Thr Pro Asn Ser Pro Val Lys Met Thr
          1170                1175                1180
       ctg att ccc agc ccc aac tca ccc ttc caa aag gtg gga aaa cta gca     3600
       Leu Ile Pro Ser Pro Asn Ser Pro Phe Gln Lys Val Gly Lys Leu Ala
      1185                1190                1195                1200
       agc tca gat aca gga gaa tca gac cag tct agc aca gaa acg gac agt     3648
       Ser Ser Asp Thr Gly Glu Ser Asp Gln Ser Ser Thr Glu Thr Asp Ser
                      1205                1210                1215
       acc gtg aaa tcc caa gaa gaa agc aac cca aaa ctg gat cca caa gag     3696
       Thr Val Lys Ser Gln Glu Glu Ser Asn Pro Lys Leu Asp Pro Gln Glu
                  1220                1225                1230
       tta gcc cag aaa att ctg gag gag aca cag agt cat ctc att gcg gtg     3744
       Leu Ala Gln Lys Ile Leu Glu Glu Thr Gln Ser His Leu Ile Ala Val
              1235                1240                1245
       gag cgt ctt cag agg agc ggc ggc cag gtg agc aag agt aat aac cct     3792
       Glu Arg Leu Gln Arg Ser Gly Gly Gln Val Ser Lys Ser Asn Asn Pro
          1250                1255                1260
       gaa gac ggc gtt cag gcg ccc agc agc act gct gtc ttc aga gcg tca     3840
       Glu Asp Gly Val Gln Ala Pro Ser Ser Thr Ala Val Phe Arg Ala Ser
      1265                1270                1275                1280
       gaa acc agt gcg ttc agc agg cct gtt ctc tcc cat cag aag agt cag     3888
       Glu Thr Ser Ala Phe Ser Arg Pro Val Leu Ser His Gln Lys Ser Gln
                      1285                1290                1295
       cca tca cca gtc act gtt aaa cca aag ccc cca gcc agg agc tcc tcc     3936
       Pro Ser Pro Val Thr Val Lys Pro Lys Pro Pro Ala Arg Ser Ser Ser
                  1300                1305                1310
       ctg ccc aag gtg agt tcc gga tat agc agc ccc acc acc tca gag atg     3984
       Leu Pro Lys Val Ser Ser Gly Tyr Ser Ser Pro Thr Thr Ser Glu Met
              1315                1320                1325
       tcc atc aaa gac agc ccg agc cag cac agt ggc cgg cca tcg ccc ggc     4032
       Ser Ile Lys Asp Ser Pro Ser Gln His Ser Gly Arg Pro Ser Pro Gly
          1330                1335                1340
       tgc gac tca cag act tcc cag ctg gac cag cct ctc ttt aaa ctg aag     4080
       Cys Asp Ser Gln Thr Ser Gln Leu Asp Gln Pro Leu Phe Lys Leu Lys
      1345                1350                1355                1360
       tac ccc agc tct cct tac agc gct cac att tcc aaa tca cca agg aac     4128
       Tyr Pro Ser Ser Pro Tyr Ser Ala His Ile Ser Lys Ser Pro Arg Asn
                      1365                1370                1375
       atg tcc cca agc tcc ggc cac cag tct cct gct ggc agt gca ccc tcc     4176
       Met Ser Pro Ser Ser Gly His Gln Ser Pro Ala Gly Ser Ala Pro Ser
                  1380                1385                1390
       cca gct ctc tcc tac tcc tca gct gga tct gct cgc tca agt cca gca     4224
       Pro Ala Leu Ser Tyr Ser Ser Ala Gly Ser Ala Arg Ser Ser Pro Ala
              1395                1400                1405
       gac gct ccc gac ata gac aaa ctg aaa atg gca gcc att gat gaa aag     4272
       Asp Ala Pro Asp Ile Asp Lys Leu Lys Met Ala Ala Ile Asp Glu Lys
          1410                1415                1420
       gtg cag gct gtc cat aac ctg aag atg ttc tgg cag agc aca ccc cag     4320
       Val Gln Ala Val His Asn Leu Lys Met Phe Trp Gln Ser Thr Pro Gln
      1425                1430                1435                1440
       cat tcc aca ggg cca atg aag atc ttc cgg ggg gct cct ggc acg atg     4368
       His Ser Thr Gly Pro Met Lys Ile Phe Arg Gly Ala Pro Gly Thr Met
                      1445                1450                1455
       act tcc aaa agg gat gtc ctc agt ctg ttg aat ttg tca cca cgg cac     4416
       Thr Ser Lys Arg Asp Val Leu Ser Leu Leu Asn Leu Ser Pro Arg His
                  1460                1465                1470
       aat aag aag gag gag gga gtg gat aag ctt gaa ctg aag gag ctg tcc     4464
       Asn Lys Lys Glu Glu Gly Val Asp Lys Leu Glu Leu Lys Glu Leu Ser
              1475                1480                1485
       ctg cag cag cat gac gga gct cca ccg aaa gcc cct ccc aac gga cac     4512
       Leu Gln Gln His Asp Gly Ala Pro Pro Lys Ala Pro Pro Asn Gly His
          1490                1495                1500
       tgg cgc acc gag acc acc tcg ctg ggc tca ctg ccg ctg ccc gcc ggc     4560
       Trp Arg Thr Glu Thr Thr Ser Leu Gly Ser Leu Pro Leu Pro Ala Gly
      1505                1510                1515                1520
       cct ccc gcc aca gcc ccc gcg cgc cct ttg agg ctt cct tct gga aat     4608
       Pro Pro Ala Thr Ala Pro Ala Arg Pro Leu Arg Leu Pro Ser Gly Asn
                      1525                1530                1535
       ggc tac aag ttc ctg tct cca gga aga ttt ttc cct tct tcc aaa tgc     4656
       Gly Tyr Lys Phe Leu Ser Pro Gly Arg Phe Phe Pro Ser Ser Lys Cys
                  1540                1545                1550
       taa                                                                 4659